Table 2.
Cytokine levels in the circulation of patients and in the conditioned media of their corresponding organoid cultures
| No cachexia | Cachexia | P value | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PANCO‐11 | PANCO‐12 | PANCO‐22 | Average | PANCO‐3 | PANCO‐5 | PANCO‐6 | PANCO‐9 | PANCO‐17 | Average | ||||
| IL‐6 (pg/mL) | CM | ‘a’ | ND | ND | — | ND | ND | ND | 2.6 | 5.4 | ND | 4.0 ± 2.0 | — |
| ‘b’ | ND | ND | ND | ND | — | — | ND | ND | |||||
| Plasma | ND | 8.6 | 5.4 | 7.0 ± 2.3 | 45.7 | 2.2 | 16.3 | 10.8 | 2.8 | 15.6 ± 17.8 | 0.7 | ||
| IL‐8 (ng/mL) | CM | ‘a’ | 0.7 | 2.0 | — | 1.3 ± 0.9 | 1.3 | 4.1 | 42.7 | 2.5 | 0.8 | 7.4 ± 14.3 | 0.07 |
| ‘b’ | 0.7 | 0.5 | 2.3 | 2.6 | — | — | 3.3 | 0.7 | |||||
| Plasma | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | — | ||
| GDF15 (ng/mL) | CM | ‘a’ | 1.1 | 1.0 | — | 1.5 ± 1.4 | 2.2 | 2.3 | 6.1 | 5.7 | 1.6 | 5.4 ± 3.6 | 0.01 |
| ‘b’ | 1.1 | 0.4 | 4.0 | 10.2 | — | — | 11.2 | 4.2 | |||||
| Plasma | 1.2 | 0.5 | 0.5 | 0.7 ± 0.4 | 0.2 | 0.3 | 0.9 | 1.5 | 0.7 | 0.7 ± 0.5 | 1.0 | ||
CM, conditioned medium; IL, interleukin; ND, not detectable.