Table 2.
Sham | PAB | AOB | Sham | PAB | AOB | |
---|---|---|---|---|---|---|
7 weeks | 7 weeks | 7 weeks | 22–26 weeks | 22 weeks | 26 weeks | |
(n = 14) | (n = 14) | (n = 14) | (n = 20) | (n = 10) | (n = 10) | |
LVEDD (mm) | 6.44 ± 0.06 | 6.73 ± 0.04 | 6.47 ± 0.05 | 6.62 ± 0.09 | 5.79 ± 0.12 * | 8.73 ± 0.08 * , §§ |
RVEDD (mm) | 2.51 ± 0.15 | 2.22 ± 0.21 | 2.10 ± 0.09 | 2.43 ± 0.18 | 5.85 ± 0.23 ** | 2.81 ± 0.14 §§ |
LVPWT (mm) | 1.35 ± 0.11 | 1.27 ± 0.04 | 1.72 ± 0.08 * , § | 1.42 ± 0.16 | 1.45 ± 0.12 | 2.01 ± 0.13 * , § |
IVSD (mm) | 0.95 ± 0.03 | 1.02 ± 0.04 | 1.13 ± 0.02 * | 0.98 ± 0.02 | 1.25 ± 0.09 * , † | 1.64 ± 0.04 ** , § |
RVWTD (mm) | 0.30 ± 0.02 | 0.42 ± 0.05 * | 0.33 ± 0.04 | 0.33 ± 0.04 | 0.52 ± 0.06 ** , † | 0.35 ± 0.03 §§ |
LV SV (μL) | 143.4 ± 9.9 | 145.1 ± 6.3 | 181.7 ± 15.2 * , § | 151.2 ± 8.5 | 148.6 ± 8.2 | 121.7 ± 12.1 * , † , § |
LV CO (mL/min) | 46.7 ± 1.2 | 46.2 ± 1.9 | 58.6 ± 2.5 * , § | 47.4 ± 0.9 | 47.8 ± 3.3 | 33.9 ± 1.2 ** , †† , § |
AOB, ascending aortic banding; PAB, pulmonary artery banding.
Echocardiographic evaluation of LVEDD (left ventricular end‐diastolic diameter), RVEDD (right ventricular end‐diastolic diameter), LVPWT (left ventricular posterior wall thickness in diastole), IVSD (interventricular septum in diastole), RVWTD (right ventricular wall thickness in diastole), LV SV (stroke volume = left ventricular end‐diastolic − left ventricular end‐systolic volume), and LV CO (cardiac output = stroke volume × heart rate).
P < 0.05.
P < 0.01 vs. respective age‐matched sham.
P < 0.05.
P < 0.01 vs. respective 7 week animals.
P < 0.05.
P < 0.01 vs. respective age‐matched PAB animals.