Table 3.

Plasma parameters at the end of the study

	Sham	PAB	AOB	Sham	PAB	AOB
	7 weeks	7 weeks	7 weeks	22–26 weeks	22 weeks	26 weeks
	(n = 14)	(n = 14)	(n = 14)	(n = 20)	(n = 10)	(n = 10)
BNP (pg/mL)	4.25 ± 2.06	36.62 ± 8.17 **	40.39 ± 8.05 **	10.54 ± 9.43	137.93 ± 21.76 *** , †	126.45 ± 17.71 *** , †
TNF‐α (pg/mL)	8.85 ± 3.26	17.29 ± 3.79 *	17.88 ± 3.51 *	8.04 ± 2.08	20.06 ± 2.44 *	42.73 ± 4.13 * , † , §
IL‐6 (pg/mL)	4.11 ± 1.25	9.43 ± 2.31 *	10.27 ± 2.68 *	5.38 ± 1.21	11.79 ± 2.74 *	19.65 ± 2.72 ** , † , §
IL‐1β (pg/mL)	26.31 ± 6.83	31.07 ± 6.36	34.14 ± 8.59	28.15 ± 6.29	52.63 ± 6.76 * , †	62.08 ± 7.14 * , †
Angiotensin II (pg/mL)	15.79 ± 3.81	24.83 ± 8.12 *	43.49 ± 6.10 ** , §	17.94 ± 5.74	35.18 ± 8.09 *	102.33 ± 5.98 *** , †† , §§

AOB, ascending aortic banding; BNP, brain natriuretic peptide; IL, interleukin; PAB, pulmonary artery banding; TNF‐α, tumour necrosis factor‐α.

Plasma concentrations of the indicated mediators as determined by enzyme‐linked immunosorbent assay.

^* P < 0.05.

^** P < 0.01.

^*** P < 0.001 vs. respective age‐matched sham.

^† P < 0.05.

^†† P < 0.01 vs. respective 7 week animals.

^§ P < 0.05.

^§§ P < 0.01 vs. respective age‐matched PAB animals.