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Domain IV of EF-G contacts the codon–anticodon duplex during translocation. In the crystal structure of a trapped chimeric hybrid-state translocation intermediate (Zhou et al. 2014), the tip of domain IV of EF-G contacts the RNA backbones of the anticodon loop of the ap/ap tRNA (yellow) and the codon of the mRNA (green) at their point of convergence. The positions of dominant-lethal mutations in loop I (red) and loop II (orange) of domain IV are indicated.
