Table 4. ROC analysis results for potential markers and their combinations.

Classes	Potential markers/ combinations	Cel-miR-39 normalization					miR-222-3p normalization
		AUC	Optimal cut-of value (point)	Specificity	Sensitivity	Accuracy	AUC	Optimal cut-of value (point)	Specificity	Sensitivity	Accuracy
Controls vs BC patients	miR-145-5p	0.932	0.535 (−12.17)	0.857	0.909	0.882	0.932	0.32 (−1.77)	0.788	0.971	0.882
	miR-16-5p	0.664	0.51 (−4.45)	0.606	0.686	0.647	–	–	–	–	–
	miR-191-5p	0.868	0.60 (−9.00)	0.939	0.714	0.824	0.904	0.421 (1.37)	0.818	0.914	0.868
	miR-21-5p	0.842	0.58 (−8.21)	0.848	0.743	0.794	0.705	0.54 (2.42)	0.848	0.714	0.779
	miR-210-3p	0.713	0.55 (−13.86)	0.758	0.657	0.706	–	–	–	–	–
	miR-222-3p	0.760	0.549 (−10.57)	0.879	0.657	0.765	–	–	–	–	–
	miR-29c-3p	0.739	0.68 (−15.23)	0.970	0.457	0.706	–	–	–	–	–
	miR-145-5p + miR-191-5p	0.930	0.52	0.879	0.886	0.882	0.984	0.72	1.000	0.943	0.971
	miR-145-5p + miR-21-5p	0.936	0.44	0.818	0.943	0.882	0.932	0.44	0.818	0.914	0.868
	miR-191-5p + miR-21-5p	0.875	0.36	0.697	0.914	0.809	0.919	0.53	0.879	0.857	0.868
	miR-145-5p + miR-191-5p + miR-21-5p	0.933	0.605	0.939	0.829	0.882	0.984	0.72	1.000	0.943	0.971
HER2- vs HER2+	miR-145-5p	–	–	–	–	–	0.751	0.15 (−0.98)	0.481	1.000	0.588
	miR-191-5p	–	–	–	–	–	0.831	0.147 (1.98)	0.667	1.000	0.735
Ki-67: <20% vs ≥20%	miR-21-5p	–	–	–	–	–	0.791	0.506 (2.55)	0.706	0.944	0.829
Tumor grade: G2 vs G3	miR-145-5p	–	–	–	–	–	0.780	0.32 (−0.25)	0.667	0.964	0.912
	miR-210-3p	–	–	–	–	–	0.845	0.10 (−3.73)	1.000	0.679	0.735