Table 2. Overview of reported direct molecular binding targets of Silibinin.

Protein name	Gene symbol	Lit.
Cytochrom P450 2C9	CYP2C9	Beckmann-Knopp et al. (2000), Kawaguchi-Suzuki et al. (2014)
		Bijak (2017), Por et al. (2018)
CXC-Motiv-Chemokinrezeptor 4	CXCR4	Wang et al. (2014a)
Mitogen-Activated Protein Kinase 11	MAPK11	Youn et al. (2013)
G-protein coupled receptor 12	GPR120	Chinthakunta et al. (2018)
Cyclooxygenase-2	COX-2	Malik, Manan & Kirza (2017)
Phospholipase A2	PLA2	Malik, Manan & Kirza (2017)
Aldo-Keto Reductase Family 1 Member D1	AKR1D1	Malik, Manan & Kirza (2017)
Core 1 β1,3-galactosyltransferase	C1GALT1	Lin et al. (2018)
β-catenin	CTNB1	Iftikhar & Rashid (2014)
Epidermal Growth Factor Receptor	EGFR	Hosen et al. (2016)
Heat Shock Protein 90	HSP90	Zhao et al. (2011), Riebold et al. (2015), Cuys et al. (2019)
Signal Transducers and Activators of Transcription 3	STAT3	Bosch-Barrera & Menendez (2015), Bosch-Barrera, Queralt & Menedez (2017)
		Verdura et al. (2018), Qin et al. (2019)