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. 2020 Oct 19;29(20):3402–3411. doi: 10.1093/hmg/ddaa230

Figure 3.

Figure 3

The Rabl2L119F/L119F and Rabl2V158F/V158F alteration cause male infertility. (A) Litter sizes from mating of Rabl2+/+ (+/+), Rabl2L119F/+ (LF/+), Rabl2L119F/L119F (LF/LF), Rabl2V158F/+ (VF/+), Rabl2V158F/V158F (VF/VF), Rabl2+/− (+/−) and Rabl2−/− (−/−) females and males to WT partners. (B) Boxplots showing the distribution of the length of sperm tails from +/+ (n = 174 from 4 mice), LF/+ (n = 158 from 3 mice), LF/LF (n = 120 from 3 mice), VF/+ (n = 83 from 2 mice), VF/VF (n = 160 from 3 mice), +/− (n = 120 from 3 mice) and −/− (n = 118 from 3 mice) mice. Black central line represents the median and boxes and whiskers represent the 25th and 75th and 2.5th and 97.5th percentiles. (C) Assessment of sperm total and progressive motilities of +/+, LF/+, LF/LF, VF/+, VF/VF, +/− and −/− mice. For each mouse, at least 100 sperms were analyzed. (D) Beat frequency (in hertz) of motile sperms from +/+, LF/+, LF/LF, VF/+, VF/VF, +/− and −/− mice. Data in A–D are represented as the mean ± SEM and were analyzed using one-way ANOVA with Tukey’s post hoc test. n.s. in A and D represents no significant difference.