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. 2020 Oct 19;29(20):3402–3411. doi: 10.1093/hmg/ddaa230

Figure 4.

Figure 4

Rabl2 mutant mice have developmental defects. (A) Comparison of body weight of +/+, LF/+, LF/LF, VF/+, VF/VF, +/− and −/− males (see legend of Fig. 3 for genotype abbreviations) at 3, 12 and 24 weeks (wk) of age. (B) Examples of laterality defects in Rabl2 altered mice. Visceral dissection demonstrates the location of heart (H), liver (L), stomach (S) and large intestine (LI). (C) Relative location of heart and lung in heterotaxic and control mice. Ventral view of lung lobes was labeled. RA, right anterior; RM, right middle; RP, right posterior; RAc, right accessory and LA, left anterior lobe. (D) Quantification of the proportion of mice with heterotaxia. (E) Representative images of the hindlimb from Rabl2 mutant mouse with polydactyly. (F) Quantification of the proportion of mice with polydactyly. Data in A are represented as the mean ± SEM and were analyzed using one-way ANOVA with Tukey’s post hoc test. Data in F were analyzed using chi-square test.