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Leptin’s role in the anterior pituitary. Leptin receptors on gonadotropes and somatotropes receive rising serum leptin which peaks at midcycle. Leptin stimulates gonadotropes to produce GnRHR proteins and Fshb and activin mRNAs in partnership with pulsatile GnRH and estradiol positive feedback. Leptin also stimulates the translation of GH and GHRHR proteins to support the cogonadotropic function of somatotropes. The products in green are the known leptin targets.
