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. 2020 Oct 19;29(20):3373–3387. doi: 10.1093/hmg/ddaa228

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Apicobasal polarity and intercellular junction assembly are maintained during OF closure in the ventral optic cup in Nf2^CKO embryos. (A, B, E, F: E11.5; C, D: E11.0) A, B: Localization of pMLC2 on the apical surface of the RPE layer appears normal in Nf2^CKO embryos (B; arrow). Asterisk marks the overlying OF. C, D: Apical distribution of the tight junction component ZO-1 is not affected in the Nf2^CKO ventral optic cup (D; arrow). The cadherin associated protein α-catenin shows normal localization in the OF and apical space between retina and RPE in Nf2^CKO eyes (F, arrows). Sagittal view with nasal orientation to the left. Scale bars: 20 μm in E, F.