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. 2020 Dec 3;80(1):21–44. doi: 10.1093/jnen/nlaa140

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© 2020 American Association of Neuropathologists, Inc. All rights reserved.

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FIGURE 6. — Staging of neurofibrillary degeneration. The percentage of neurons with neurofibrillary tangles (NFTs) ranging from 0 in Purkinje cells (not shown) to 81.2% in the second layer of the entorhinal cortex (EC) in severe Alzheimer disease, illustrates a broad spectrum of regional neuronal susceptibility to neurofibrillary degeneration. Regional differences are accentuated by a several-fold-higher percentage of neurons with NFTs in the CA1 than in 3 other segments of the cornu Ammonis (graph A). Stage-specific rate of neurofibrillary degeneration is reflected in an increase in the mean percentage of neurons with NFTs from 7% in the control group to 13% in FAST stages 3–4, 24% in FAST stages 5–6, and 31% in FAST stage 7 (graph B). Opposite directions of neurofibrillary degeneration in FAST stage 7a–f are documented by regional losses of neurons with NFTs in CA1, EC islands, subiculum, CA4, and the entire EC (graph C) and a simultaneous increase in the percentage of neurons with NFTs in the amygdala and thalamus (graph D).