TABLE 4.

Number of Neurons in AD Subjects FAST Stages 3–4 and 5–6 and Estimated Loss of Neurons in FAST Stages 5–6

Structure/Subdivision	Mean Number of Neurons ± SE		Neuronal Loss in FAST Stages 5–6
	AD Subjects FAST 3–4	AD Subjects FAST 5–6	Number	p <	Loss (%)	Loss/Day	Loss/Million Neurons/Day
Entorhinal c. (All layers)	7 477 533 ± 588 796	5 659 375 ± 558 432	1 818 158	0.047	18.7	2255	302
Entorhinal c. (Islands)	516 637 ± 53 472	285 111 ± 29 133	231 526	0.002	34.4	287	556
CA1	7 755 632 ± 604 472	4 729 351 ± 560 656	3 026 281	0.003	29.5	3753	484
CA2	1 080 495 ± 119 308	1 008 257 ± 89 234	72 238	ns	4.6	—	—
CA3	862 857 ± 89 455	816 355 ± 49 942	46 502	ns	3.9	—	—
CA4	1 116 072 ± 111 167	981 907 ± 71 632	134 165	ns	—	—	—
Subiculum	2 955 600 ± 117 177	2 350 660 ± 116 370	604 940	0.003	15.2	750	254
Amygdala	5 383 510 ± 502 552	5 013 979 ± 305 068	369 531	ns	3.6	458	85
Thalamus	12 268 846 ± 460 388	9 186 080 ± 419 578	3 082 766	0.0002	13.6	3823	312
Substantia nigra	337 728 ± 19 725	333 152 ± 24 338	4576	ns	—	—	—
Magno-cellular basal complex	983 291 ± 41 654	633 343 ± 47 129	349 948	0.0001	35.6	434	441
Caudate nucleus	32 722 049 ± 2 900 707	32 558 855 ± 1 880 536	0	(ns)	—	—	—
Purkinje cells	13 109 496 ± 803 390	10 217 518 ± 1 346 464	2 891 978	(ns)	—	—	—
Dentate nucleus	578 193 ± 45 776	529 793 ± 35 930	48 400	(ns)	—	—	—

Percentage of neuronal loss estimated in comparison to control group. The rate of neuronal loss estimated as number of lost neurons per day and number/million neurons/day in FAST stages 5–6.

AD, Alzheimer disease; CA1, sector 1 of the cornu Ammonis; FAST, Functional Assessment Staging; ns, no statistically significant neuronal loss.