TABLE 5.
Number of Neurons in AD Subjects FAST Stages 5–6 and 7 and Estimated Neuronal Loss in FAST Stage 7
| Structure/Subdivision | Mean Number of Neurons ± SE |
Neuronal Loss in FAST 7 |
|||||
|---|---|---|---|---|---|---|---|
| AD Subjects FAST 5-6 |
AD Subjects FAST 7 | Number | p < | Loss % | Loss/Day | Loss/Million Neurons/Day | |
|
Entorhinal c. (All layers) |
5 659 375 ± 558 432 | 3 545 875 ± 429 688 | 2 113 500 | 0.010 | 21.7 | 334 | 61 |
| Entorhinal c. (Islands) | 285 111 ± 29 133 | 109 499 ± 23 877 | 175 612 | 0.0004 | 26.1 | 29 | 100 |
| CA1 | 4 729 351 ± 560 656 | 2 236 355 ± 503 577 | 2 492 996 | 0.005 | 24.3 | 405 | 86 |
| CA2 | 1 008 257 ± 89 234 | 879 922 ± 74 304 | 128 335 | ns | 8.2 | — | — |
| CA3 | 816 355 ± 49 942 | 816 611 ± 79 005 | 0 | ns | — | — | — |
| CA4 | 981 907 ± 71 632 | 888 282 ± 92 711 | 93 625 | ns | — | — | — |
| Subiculum | 2 350 660 ± 116 370 | 1 762 900 ± 178 799 | 587 760 | 0.011 | 14.8 | 96 | 41 |
| Amygdala | 5 013 979 ± 305 068 | 4 348 692 ± 279 369 | 665 287 | ns | 6.5 | — | — |
| Thalamus | 9 186 080 ± 419 578 | 7 329 607 ± 335 924 | 1 856 473 | 0.004 | 8.2 | 302 | 33 |
| Substantia nigra | 333 152 ± 24 338 | 245 924 ± 33 436 | 87 228 | ns | — | — | — |
|
Magno-cellular basal complex |
633 343 ± 47 129 | 549 995 ± 63 304 | 83 348 | ns | — | — | — |
| Caudate nucleus | 32 558 855 ± 1 880 536 | 27 376 562 ± 2 645 305 | 5 182 293 | ns | — | — | — |
| Purkinje cells | 10 217 518 ± 1 346 464 | 10 267 816 ± 648 072 | 0 | ns | — | — | — |
| Dentate nucleus | 529 793 ± 35 930 | 522 343 ± 40 897 | 7450 | ns | — | — | — |
Percentage of neuronal loss estimated in comparison to control group. The rate of neuronal loss estimated as number of lost neurons per day and number/million neurons/day in FAST stage 7.
AD, Alzheimer disease; CA1, sector 1 of the cornu Ammonis; FAST, Functional Assessment Staging; ns, no statistically significant neuronal loss.