TABLE 6.
Brain Region and Neuron Type Specific Number and Percentage of Neurons With Neurofibrillary Tangles in Control Subjects and in AD FAST Stages 3–4, 5–6, and 7
| Structure/Subdivision | Control (69–102 Years) |
AD FAST 3–4 |
AD FAST 5–6 |
AD FAST 7 |
||||
|---|---|---|---|---|---|---|---|---|
| Number (SE) | % | Number (SE) | % | Number (SE) | % | Number (SE) | % | |
| Entorhinal c. (all layers) | 1 137 400 (171 955) | 11.6 | 1 787 782 (141 764) | 24.4 | 1 808 946 (246 456) | 32.9 | 1 571 175 (260 081) | 43.9 |
| Entorhinal c. (islands) | 137 072 (18 454) | 21.3 | 166 243 (20 450) | 33.5 | 160 112 (26 559) | 58.01 | 89 441 (19 683) | 84.9 |
| CA1 | 1 267 690 (201 925) | 12.2 | 2 281 756 (593 078) | 30.3 | 2 615 099 (271 304) | 58.1 | 1 331 511 (316 440) | 55.1 |
| CA2 | 71 278 (15 349) | 4.4 | 106 926 (30 223) | 9.9 | 159 046 (35 648) | 15.5 | 157 116 (32 558) | 17.9 |
| CA3 | 24 600 (4757) | 2.0 | 63 284 (20 779) | 8.8 | 91 962 (23 027) | 11.2 | 100 331 (16 295) | 12.5 |
| CA4 | 60 525 (10 525) | 4.5 | 129 633 (35 220) | 11.2 | 182 610 (38 616) | 18.3 | 156 339 (32 189) | 21.0 |
| Subiculum | 216 669 (43 838) | 5.4 | 332 050 (95 041) | 11.2 | 496 519 (32 591) | 21.5 | 336 878 (30 208) | 19.5 |
| Amygdala | 904 717 (262 576) | 8.9 | 644 262 (143 074) | 12.7 | 1 404 371 (233 755) | 28.0 | 1 784 112 (253 702) | 40.2 |
| Thalamus | 13 613 (9855) | 0.1 | 201 492 (84 178) | 1.6 | 1 120 090 (168 885) | 12.3 | 1 810 456 (177 997) | 24.5 |
| Substantia nigra | 2980 (2094) | 0.5 | 8038 (1700) | 2.4 | 18 834 (3566) | 5.9 | 18 613 (2931) | 7.9 |
| Magno-cellular basal complex | 32 033 (10 756) | 3.4 | 60 287 (14 650) | 6.2 | 62 099 (14 840) | 10.4 | 58 063 (17 403) | 9.9 |
| Caudate nucleus |
3616 (3616) |
0.01 | 291 796 (197 443) | 0.9 | 140 130 (49 330) | 0.4 | 348 780 (123 775) | 1.4 |
| Purkinje cell | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dentate nucleus | 0 | 0.0 |
1104 (823) |
0.2 |
3645 (1142) |
0.7 |
3492 (1610) |
0.7 |
AD, Alzheimer disease; CA1, sector 1 of the cornu Ammonis; FAST, Functional Assessment Staging.