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. 2020 Nov 27;2(2):fcaa207. doi: 10.1093/braincomms/fcaa207

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© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Median entropy in different brain regions across healthy, cog. stable and cog. declining participants. Median entropy values are shown for the HCs (green, n = 24) as well as for the extreme groups of cognitively stable individuals (yellow, n = 10) and cognitive decliners (red, n = 10). The most prominent difference involves a distinctly reduced TE at baseline for patients showing a strong 3-year cognitive decline. The cognitively most stable patients are indistinguishable from HCs based on their regional TE levels. With no apparent regional differences, decreasing TE of the θ-band during the course of Parkinson’s disease is likely a global effect not attributable to a single location.