Table 1.
Corrected [11C]PBR28 VT values and cognitive task scores pre- and post-LPS administration
| Region | Pre-LPS | Post-LPS | % Change | t value | Pvalue | Cohen’s d | |
|---|---|---|---|---|---|---|---|
| Corrected [11C]PBR28 VT Values | Composite of regions* | 5.38 (1.18) | 7.51 (1.50) | 41.0% | 10.15 | .000 | 2.39 |
| Caudate* | 4.16 (0.85) | 6.14 (1.57) | 47.1% | 7.62 | .000 | 1.80 | |
| Cerebellum* | 5.72 (1.22) | 7.89 (1.48) | 39.4% | 9.92 | .000 | 2.34 | |
| Frontal* | 5.54 (1.11) | 7.80 (1.64) | 41.5% | 9.40 | .000 | 2.21 | |
| Hippocampus* | 5.19 (1.35) | 7.05 (1.32) | 38.6% | 9.47 | .000 | 2.23 | |
| Insula* | 5.32 (1.17) | 7.20 (1.36) | 36.5% | 10.64 | .000 | 2.51 | |
| Occipital* | 6.07 (1.34) | 8.55 (2.23) | 41.3% | 6.91 | .000 | 1.63 | |
| Parietal* | 5.73 (1.17) | 8.60 (2.14) | 50.3% | 7.65 | .000 | 1.80 | |
| Putamen* | 4.85 (1.14) | 6.78 (1.34) | 41.6% | 9.70 | .000 | 2.29 | |
| Temporal* | 5.28 (1.16) | 7.46 (1.60) | 42.1% | 8.66 | .000 | 2.04 | |
| Thalamus* | 5.91 (1.63) | 7.66 (1.70) | 31.1% | 13.37 | .000 | 3.15 | |
| Cognitive Tasks | Psychomotor Speed | 2.49 (0.11) | 2.49 (0.10) | 0.1% | 0.14 | .89 | 0.03 |
| Visual Attention | 2.69 (0.09) | 2.71 (0.09) | 0.8% | 1.42 | .17 | 0.33 | |
| Executive Function | 48.44 (15.94) | 46.94 (14.76) | −3.1% | 0.47 | .65 | 0.11 | |
| Visual Working Memory | 1.33 (0.22) | 1.26 (0.25) | −5.4% | 1.73 | .10 | 0.43 | |
| Visual Learning | 1.00 (0.14) | 0.93 (0.19) | −7.2% | 2.40 | .03 | 0.58 | |
| Verbal Learning* | 27.06 (4.28) | 24.06 (5.17) | −10.7% | 4.21 | .001 | 0.99 | |
| Verbal Recall* | *9.47 (1.94) | 7.35 (3.37) | −22.3% | 4.24 | .001 | 1.03 | |
Note. LPS = lipopolysaccharide. Cognitive tasks are from the computerized Cogstate battery (www.cogstate.com).
*
Asterisks denote a statistically significant change following LPS administration after Bonferroni-correction for multiple comparisons: p<.005 (.05/10 brain regions) for [11C]PBR28 VT values and p<.007 (.05/7 cognitive tasks) for cognitive measures. Cohen’s d effect size interpretation: ‘small’ ≤0.2; ‘moderate’ =0.5; and ‘large’ ≥0.8.