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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Brain Behav Immun. 2020 Sep 19;91:587–600. doi: 10.1016/j.bbi.2020.09.016

Figure 4. Intranasal administration of INT-777 reduced ipsilateral hemisphere NLRP3-ASC inflammasome activation in microglia at 24 h after SAH.

Figure 4.

(A) Representative immunofluorescence micrographs of NLRP3 (red) or ASC (red) with Iba-1 (green) in the ipsilateral basal cortex for sham, SAH+Vehicle, and SAH+INT-777 groups. Nuclei were stained with DAPI (blue). Scale bar=50 μm. (B) A small black squares in the coronal section of brain indicated the area used for microphotographs. (C-D) Quantitative analysis of NLRP3-positive and ASC-positive microglia. n=4 per group. Vehicle: 10% dimethyl sulfide. Data was represented as mean ± SD. *P<0.05 vs. Sham group; @P<0.05 vs. SAH+Vehicle group.