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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Brain Behav Immun. 2020 Sep 19;91:587–600. doi: 10.1016/j.bbi.2020.09.016

Figure 6. TGR5 knockout CRISPR abolished the anti-neuroinflammation effects of INT-777 at 24 h after SAH.

Figure 6.

(A) Representative western blot bands and (B-I) quantification of TGR5, cAMP, p-PKA/PKA, NLRP3, ASC, IL-1β, IL-6, and TNF-a. Vehicle: 10% dimethyl sulfide. n=6 per group. Data was represented as mean ± SD. *P<0.05 vs. Sham group, @P<0.05 vs. SAH+Vehicle group, &P<0.05 vs. SAH+Scrambled CRISPR group.