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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Brain Behav Immun. 2020 Oct 8;91:296–314. doi: 10.1016/j.bbi.2020.10.008

Fig. 12.

Fig. 12.

Dexmedetomidine remained to be effective to reduce systemic inflammation and neuroinflammation in septic mice depleted of microglia. (A) Presentation of microglial depletion by PLX3397. Left panel is representative images of Iba-1 immunostaining. Scale bar = 500 μm. Right panel is quantification of Iba-1 positive cells. (B) Representative Western blotting images. (C) Concentrations of IL-6 and IL-1β in the serum and concentrations of C3, IL-6 and IL-1β in the hippocampus. All results are expressed as mean ± S.D. (n = 4 for panel A; n = 6 in each group for all other panels). Each animal data point in the bar graph is also presented. PLX: PLX3397, Dex: dexmedetomidine.