Skip to main content
. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Brain Behav Immun. 2020 Oct 8;91:296–314. doi: 10.1016/j.bbi.2020.10.008

Fig. 9.

Fig. 9.

Intracerebroventricular α2A adrenoceptor antagonist (BRL-44408) reduced dexmedetomidine protection on sepsis-impaired learning, memory and BBB integrity in mice. (A) Training sessions of Barnes maze. (B) Memory phase of Barnes maze. (C) Context- and tone-related fear conditioning test. (D) Representative Western blotting images of samples from the hippocampus. (E) Quantitative results of HMGB1 and RAGE in the hippocampus. (F) Quantification of Evans blue permeated into the hippocampus. All results are expressed as mean ± S.D. (n = 10 – 12 in each group for panels A to C; n = 6 in each group for Western blotting data; n = 6 in each group for Evans blue quantification data). Each animal data point in the bar graph is also presented. * P < 0.05 compared with the corresponding data on day 1. BRL: BRL-44408, Dex: dexmedetomidine.