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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: J Hepatol. 2020 Aug 4;74(1):156–167. doi: 10.1016/j.jhep.2020.07.041

Figure 3. Caspase-1 activity increases in liver and serum of NASH patients and correlates with liver injury severity.

Figure 3.

(A) Active caspase-1 levels were analyzed in frozen liver tissue sections (n 3 per group). Nuclei were stained with DAPI. Fluorescence intensity was analyzed using ImageJ and normalized on DAPI positive cells. Statistical significance was tested using One-way ANOVA and Bonferroni post-hoc test. (*p< 0.05 vs. control, scale bar: 100 μm). Level of serum caspase-1 activity in patients with present or absent (B) Steatosis, (C) Inflammation, (D) Ballooning and (E) Fibrosis stage. Two groups were analyzed by Studentś T-test (*p< 0.05 vs. control).