Table 2.
Histopathologic findings in CTD by disease.
| Compartment | Histologic pattern | RA | SLE | PSS | PM/DM | SS | MCTD | AS |
|---|---|---|---|---|---|---|---|---|
| Alveolar parenchyma | NSIP | |||||||
| UIP | x | x | x | x | x | x | ||
| OP | x | x | x | x | x | x | ||
| DAD | x | x | x | x | x | |||
| LIP | x | x | x | |||||
| CIP | x | x | x | |||||
| Lymphoid hyperplasia | x | x | x | |||||
| Alveolar hemorrhage | x | x | x | |||||
| Pleura | Pleuritis/fibrosis | x | x | x | x | x | x | |
| Airways | Bronchitis/bronchiolitis | x | x | x | ||||
| Follicular bronchiolitis | x | x | x | |||||
| Constrictive bronchiolitis | x | x | x | |||||
| Vessels | Pulmonary hypertension | x | x | x | x | x | x | |
| Vasculitis | x | x | x | x | ||||
| Capillaritis | x | |||||||
| Other | Other histologic findings | Necrobiotic nodules | Hematoxylin bodies | Aspiration | Aspiration | TBGA | AFBC |
NSIP: non-specific interstitial pneumonia; UIP: usual interstitial pneumonia; OP: organizing pneumonia; DAD: diffuse alveolar damage; LIP: lymphoid interstitial pneumonia; CIP: cellular interstitial pneumonia; TBGA: tracheobronchial gland atrophy; AFBC: apical fibrobullous change.
Modified from Colby 1998, and Schneider 2012. X means presence of interstitial lung disease or interstitial lung abnormality of histologic pattern. For frequency of the pattern in each connective tissue disease, please refer to authors’ reference [5](Kim EA et al. Radiographics 22 Spec No (2002) S151-S165).