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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Exp Neurol. 2020 Oct 29;335:113520. doi: 10.1016/j.expneurol.2020.113520

Table 1.

84 microtubule-associated proteins that change in levels in iSNs from bortezomib exposure.

GO Classification Gene ID
Protein level changes of higher significance (p < 0.0001)
Biological Process Cellular Component Molecular Function −log(p-value) > 4 Increased: PAFAH1B1
Decreased: CLASP1, CLASP2, CKAP5, MAP2, MAP4, DST, MAP1B, MAP1S, ARHGEF2, KIF2A
Biological Process −log(p-value) > 4 Increased: UBB, OPA1, TBCD, IFT140, WDR35,
Decreased: DOCK7, SRGAP2, KTN1, OBSL1, GCC2, SLK, CEP131, PHLDB2, SON, MYH9, PHLDB1, FLNA
Cellular Component −log(p-value) > 4 Increased: OBSL1, TBCD, IFT140, MFN2, KLHL42, WDR35,
Decreased: CC2D1A, IQGAP1, CEP131, RANBP2, MYH9, TAPT1, AKAP11, CHAMP1
Molecular Function −log(p-value) > 4 Increased: OPA1
Decreased: NEFM
Protein level changes of lower significance (0.0001 < p < 0.05)
Biological Process Cellular Component Molecular Function −log(p-value) < 4 Increased: KIF5A, CENPE
Decreased: EML4, NUMA1, KIF5B, MAP1A, GOLGA2, APC, HDAC6, CAMSAP2, CLIP1, TUBGCP6, TRPV4, KIF13B
Biological Process −log(p-value) < 4 Increased: IFT122, TUBB, CUL9
Decreased: BCAS3, EPHA3, UCHL1, PTK2, ROCK2, TACC1, NEFL, KLC1, KPNB1, ABL1, PCM1DLG1
Cellular Component −log(p-value) < 4 Increased: RAN, IFT80, SARM1, IFT122, TUBB, CENPF, ALS2, RAB8A, KLC1, PRKCI
Decreased: TLN1, BCAS3, DAAM1, PTPN23, CEP170, MARCKS, DIAPH1, PTK2, ARHGAP35, ROCK2, TACC1, PCM1, DLG1, NEK1

underlined proteins are well correlated (r > ∣0.8∣ to at least one other protein in this list)