Figure 1.

Transient interactions control membrane functions. (A) During T-cell signaling, the MHCp ligand binding induces dynamic protein–protein interactions between T-cell receptor (TCR) and CD4. (B) The strength of lipid–lipid interactions regulates membrane phase separation and domain formation. White circles represent that lipids prefer ordered domain. The darker the blue shading of circles, the poorer the ability of these disordered phase-preferred lipids to pack tightly. (C) The correlation between membrane protein location and their interactions with lipids. Membrane lipids can be thus categorized into three groups: bulk, annular, and non-annular. (D) Dynamic cholesterol interaction with TCR regulates its activation and prevents non-specific responses.