Table 3.

Associations of Lp(a) levels with CAC progression^*

	CAC progression
	1–100 U/year					>100 U/year
	Events/# at risk	Model 1† RR (95% CI)	p-value	Model 2‡ RR (95% CI)	p-value	Events/# at risk	Model 1 RR (95% CI)	p-value	Model 2 RR (95% CI)	p-value
Lp(a) level
<30 mg/dL	2289/4017	1.00		1.00		255/4017	1.00		1.00
≥30 mg/dL	1069/1958	1.07 (0.93, 1.23)	0.34	1.00 (0.86, 1.16)	0.97	146/1958	1.50 (1.16, 1.92)	0.002	1.48 (1.12, 1.95)	0.005
<50 mg/dL	2716/4794	1.00		1.00		297/4794	1.00		1.00
≥50 mg/dL	642/1181	1.05 (0.92, 1.19)	0.49	1.00 (0.87, 1.15)	0.98	104/1181	1.81 (1.38, 2.39)	<0.001	1.67 (1.23, 2.27)	0.001

CAC=coronary artery calcification, RR=relative risk

^*Results of multivariable relative risk regression models

^†Model 1 adjusted for age, sex, race, education, and clinic site

^‡Model 2 adjusted for Model 1 + cigarette smoking, body mass index, diabetes, hypertension, family history of coronary heart disease, total cholesterol, HDL cholesterol, eGFR, hs-CRP, statin use, and aspirin use