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. Author manuscript; available in PMC: 2022 Mar 2.
Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 15;106:110064. doi: 10.1016/j.pnpbp.2020.110064

Figure 2.

Figure 2.

Dose response effects of THC at the beginning of the study (unfilled symbols) and at the end of the study (filled symbols) in female (circles) and male (squares) adult C57Bl/6J mice trained to discriminate 5.6 mg/kg THC from vehicle. Top panel shows THC effects on percentage of nose-pokes that occurred on the THC-associated aperture and bottom panel shows overall response rate. Control tests with vehicle (V) and the 5.6 mg/kg THC training dose (T) are shown at the left side of the panels. Each point represents the mean (± SEM) of data for 15 female and 20 male C57Bl/6J mice, except for n=13 for %THC aperture responding for 10 mg/kg THC in the second dose-effect curve for females (i.e., data for 2 female mice were excluded due to fewer than 10 overall responses). Dollar sign ($) indicates a significant main effect for sex across all doses (p<0.05) during the first THC dose-effect curve.