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. Author manuscript; available in PMC: 2022 Mar 2.
Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 15;106:110064. doi: 10.1016/j.pnpbp.2020.110064

Table 1.

CB1 receptor affinity and efficacy in rodent cerebellum.

Ligand CB1 Binding Affinity (Ki in nM) Potency (EC50 ± SEM) nM Efficacy (Emax ± SEM) %
Female Male Female Male Female Male
Mice
THC 37.5
(0.06)		 41.3
(0.09)		 68.2
(15.0)		 64.6
(12.4)		 69
(4.65)		 56
(3.76)
11-OH-THC 28.5
(0.03)		 27.3
(0.04)		 81.4
(27.2)		 85.3
(20.1)		 60
(139)		 52
(5.94)
CP55,940 0.48
(0.07)		 0.56
(0.06)		 nd nd nd nd
Rats
THC 36.2
(4.61)		 44.3
(10.27)		 47.9
(12.58)		 43.3
(7.33)		 43.5
(6.69)		 40.5
(2.84)
11-OH-THC 26.5
(140)		 28
(3.79)		 108.6
(13.06)		 69.8
(9.97)		 51.4
(5.74)		 51.7
(5.42)
CP55,940 0.62
(0.10)		 0.53
(0.06)		 nd nd nd nd

N = 4 / value