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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Exp Neurol. 2020 Oct 29;335:113521. doi: 10.1016/j.expneurol.2020.113521

Figure 6: Intracaudate injection of PRX-2 cause less brain damage and neurological deficits in female LCN-2 deficient mice.

Figure 6:

Female WT, LCN-2 HET and LCN-2 KO mice had an intracerebral injection of PRX-2. A) Representative T2 MRIs at day 1 after an intracerebral injection of PRX-2. Brain swelling was assessed by ventricular compression at day 1. Values are mean ± SD. n=8, #P < 0.01 vs. WT by one-way ANOVA. B) Fluoro-Jade C staining showing degenerative neurons in the ipsilateral BG at day 1. Results are mean ± SD. n=6, #P < 0.01 vs. the WT group; *P<0.05 vs. the KO group by one-way ANOVA with Tukey’s post-hoc test. Scale bar =20 μm. C) MPO staining in the ipsilateral BG at day 1. Values are mean ± SD. n=6, #P < 0.01 vs. WT and HET groups; ##P<0.01 vs. WT group by one-way ANOVA with Tukey’s post-hoc test. Scale bar = 20 μm. D) Forelimb use asymmetry and corner turn tests at pre-test (n=14), day 1 (n=14), day 3 (n=8), day 7 (n=8), and day 14 (n=8). Results are mean ± SD, *P<0.05 vs. the WT group at day 1, #P < 0.01 vs. the WT group at day 3 by one-way ANOVA with Tukey’s post-hoc test.