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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Exp Neurol. 2020 Nov 4;335:113523. doi: 10.1016/j.expneurol.2020.113523

Fig. 6. Genes causing fPD and other genetic diseases of the CNS.

Fig. 6.

(A) Box and violin plots showing the full distribution of the gene proximity to its telomere over chromosome (chr) 1 to 22. (B) Box and violin plots showing the full distribution of A + T content over chromosome (chr) 1 to 22. fPD: familial Parkinson’s disease (A and B). (C) Bar graph demonstrating factors-fPD matching rate. Total number of genes, N = 17. Success (matching) rate at 59%. See also Table S6. (D) Scattered plot showing 17 genes causing fPD with proximity to telomeres over full-length size of the gene (bp). A horizontal dotted line indicates 50 Mbp. (E) Scattered plot summarizing 17 genes causing fPD with A + T content over full-length size of the gene (bp). A horizontal dotted line indicates A + T content at 59%. F(i) and F(ii) indicate the first and second factor, respectively. **, P < 0.01 (F) Bar graph demonstrating the factor-other diseases of the CNS matching rate. Total number of genes, N = 16. NF; neurofibromatosis (n = 2); TSC; tuberous sclerosis disease (n = 2); BBS (n = 5); HD (n = 1); CNS malformations involving agenesis of corpus callosum (cc; n = 6). Success (matching) rate at ~60%. See also Table S7.