Table 4.

Univariable and Multivariable Linear Mixed Models of the Effect of Each Clinical Characteristic on the Rate of Change of Spectral-Domain Optical Coherence Tomography Retinal Nerve Fiber Layer (RNFL) Thickness Over Time.

Characteristic	Univariable Model		Multivariable Model 1		Multivariable Model 2
	Coefficient	P‒value	Coefficient	P‒value	Coefficient	P‒value
Diagnosis,
GS	0 (base)		0 (base)		0 (base)
POAG	−0.084	0.005	−0.148	<0.001	−0.124	0.001
Other	−0.242	<0.001	−0.241	<0.001	−0.205	<0.001
Age at baseline, per 10 years older	−0.028	0.006	−0.063	<0.001	−0.055	<0.001
Sex, female	0.041	0.116	0.053	0.089	0.046	0.132
Race, Black or African American	−0.055	0.056	−0.028	0.451	−0.019	0.594
Follow-up, years	−0.011	0.092	−0.038	<0.001	−0.034	<0.001
Baseline mean global RNFL thickness, per 10μm thicker	−0.045	0.001	−0.050	<0.001	−0.063	<0.001
CCT, per40μm thinner	0.007	0.551	−0.019	0.262	−0.012	0.431
Average IOP during follow-up, per 1 mmHg higher	−0.054	<0.001	−0.051	0.001	---	---
Peak IOP during follow-up, per 1 mmHg higher	−0.049	<0.001	---	---	−0.038	<0.001

Boldface indicates statistical significance (P<0.05).

CCT = central corneal thickness; IOP = intraocular pressure; GS = glaucoma suspect; POAG = primary open-angle glaucoma; SD = standard deviation; RNFL = Retinal Nerve Fiber Layer.