Table 1a:
Normal | RVD | RVD+KTP-ELP-VEGF | |
---|---|---|---|
Body weight (kg) | 45.6 ± 1.1 | 44.8 ± 1.4 | 46.6 ± 2.5 |
Mean arterial pressure (mm Hg) | 111.7 ± 2.1 | 131.8 ± 8.0* | 132.4 ± 6.7* |
Renal artery stenosis (%) | 0 | 70 ± 7.4* | 71.3 ± 3.4* |
Cortical perfusion (mL/min/cc tissue) | 3.9 ± 0.3 | 3.2 ± 0.6* | 3.1 ± 0.1* |
Medullary perfusion (mL/min/cc tissue) | 1.8 ± 0.3 | 1.9 ± 0.6 | 1.85 ±0.4 |
RVR (mm Hg/mL per min) | 0.31 ± 0.05 | 0.60 ± 0.12* | 0.66 ± 0.07* |
Renal volume (cc) | 124.7 ± 8.3 | 69.3 ± 6.4* | 82.0 ± 3.4*† |
Values are expressed as mean ± SEM. Renal vascular resistance (RVR) was quantified as mean systolic blood pressure divided by renal blood flow.
p<0.05 vs normal
p<0.05 vs untreated RVD