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. Author manuscript; available in PMC: 2022 Jan 10.
Published in final edited form as: Neurosci Lett. 2020 Nov 5;741:135486. doi: 10.1016/j.neulet.2020.135486

Table 1.

Characteristics of the cohort of PD-N and two motor phenotypes.

PD-N
(n=34)
TD-N
(n=19)
PIGD-N
(n=15)
p value
(TD-N vs. PIGD-N)
Demographics
Age (years) 57.50 ± 7.79 57.26 ± 7.82 57.80 ± 8.03 0.846
Gender (M/F) # 11M/ 23F 5M/ 14F 6M/ 9F 0.701
Education (years) 15.31 ± 2.11 14.89 ± 1.94 15.80 ± 2.34 0.237
Disease-related symptoms
MMSE 29 ± 1.7 29 ± 2.4 29 ± 0.5 0.307
Disease duration (years) 12.79 ± 6.29 12.53 ± 5.63 13.13 ± 7.22 0.791
LED (mg/day) 901.30 ± 509.31 881.69 ± 554.36 926.80 ± 472.28 0.835
UPDRS III OFF 39.71±12.64 40.68 ±13.71 38.47 ±11.47 0.611
UPDRS III ON 33.23 ± 12.81 33.57 ±12.21 32.38 ± 13.42 0.831
Tremor score 1.85 ± 1.25 2.67 ± 1.03 0.82 ± 0.52 < 0.001*^
Rest tremor 0.45 ± 0.19 0.39 ± 0.19 0.53 ± 0.16 0.026*
Active tremor 0.22 ± 0.10 0.19 ± 0.10 0.27 ± 0.08 0.014*
PIGD score 1.70 ± 0.60 1.61 ± 0.60 1.89 ±0.54 0.163
Rigidity score 1.35 ± 0.89 1.14 ± 0.85 1.63 ± 0.91 0.118
Bradykinesia score 2.23 ± 0.95 1.95 ± 0.97 2.67 ± 0.82 0.025*
DRS-II 138.74 ± 4.85 138.58 ± 5.14 138.93 ± 3.94 0.823
BDI 7.27 ± 5.37 8.63 ± 5.97 5.53 ± 4.03 0.081
FSIQ 101.7 ± 13.15 104.63 ± 14.42 98.6 ± 11.3 0.181

Note: Paired-sample two-tailed t-tests were used to measure group differences between PIGD-N and TD-N phenotypes. Values are reported uncorrected for multiple comparisons.

*

statistically significant (p < 0.05).

^

survives Bonferroni correction.

#

calculated by fisher test.MMSE = the Mini-Mental State Examination. LED = Levodopa dosage equivalence. UPDRS-III = Unified Parkinson’s Disease Rating Scale part III. DRS-II = Dementia rating scale-II. BDI = Beck Depression Inventory. FSIQ = Full Scale Intelligence Quotient. The following motor scores were from items in UPDRS-III. Tremor score = the sum of items 20 and 21, divided by 4. Rest tremor score = the sum of item 20 divided by 5. Active tremor score = the sum of item 21 divided by 2. PIGD score = the sum of items 22–27 and 31, divided by 15 from. Rigidity score = the sum of item 22 divided by 5. Bradykinesia score = item 23.