Table 1.
PD-N (n=34) |
TD-N (n=19) |
PIGD-N (n=15) |
p value (TD-N vs. PIGD-N) |
|
---|---|---|---|---|
Demographics | ||||
Age (years) | 57.50 ± 7.79 | 57.26 ± 7.82 | 57.80 ± 8.03 | 0.846 |
Gender (M/F) # | 11M/ 23F | 5M/ 14F | 6M/ 9F | 0.701 |
Education (years) | 15.31 ± 2.11 | 14.89 ± 1.94 | 15.80 ± 2.34 | 0.237 |
Disease-related symptoms | ||||
MMSE | 29 ± 1.7 | 29 ± 2.4 | 29 ± 0.5 | 0.307 |
Disease duration (years) | 12.79 ± 6.29 | 12.53 ± 5.63 | 13.13 ± 7.22 | 0.791 |
LED (mg/day) | 901.30 ± 509.31 | 881.69 ± 554.36 | 926.80 ± 472.28 | 0.835 |
UPDRS III OFF | 39.71±12.64 | 40.68 ±13.71 | 38.47 ±11.47 | 0.611 |
UPDRS III ON | 33.23 ± 12.81 | 33.57 ±12.21 | 32.38 ± 13.42 | 0.831 |
Tremor score | 1.85 ± 1.25 | 2.67 ± 1.03 | 0.82 ± 0.52 | < 0.001*^ |
Rest tremor | 0.45 ± 0.19 | 0.39 ± 0.19 | 0.53 ± 0.16 | 0.026* |
Active tremor | 0.22 ± 0.10 | 0.19 ± 0.10 | 0.27 ± 0.08 | 0.014* |
PIGD score | 1.70 ± 0.60 | 1.61 ± 0.60 | 1.89 ±0.54 | 0.163 |
Rigidity score | 1.35 ± 0.89 | 1.14 ± 0.85 | 1.63 ± 0.91 | 0.118 |
Bradykinesia score | 2.23 ± 0.95 | 1.95 ± 0.97 | 2.67 ± 0.82 | 0.025* |
DRS-II | 138.74 ± 4.85 | 138.58 ± 5.14 | 138.93 ± 3.94 | 0.823 |
BDI | 7.27 ± 5.37 | 8.63 ± 5.97 | 5.53 ± 4.03 | 0.081 |
FSIQ | 101.7 ± 13.15 | 104.63 ± 14.42 | 98.6 ± 11.3 | 0.181 |
Note: Paired-sample two-tailed t-tests were used to measure group differences between PIGD-N and TD-N phenotypes. Values are reported uncorrected for multiple comparisons.
statistically significant (p < 0.05).
survives Bonferroni correction.
calculated by fisher test.MMSE = the Mini-Mental State Examination. LED = Levodopa dosage equivalence. UPDRS-III = Unified Parkinson’s Disease Rating Scale part III. DRS-II = Dementia rating scale-II. BDI = Beck Depression Inventory. FSIQ = Full Scale Intelligence Quotient. The following motor scores were from items in UPDRS-III. Tremor score = the sum of items 20 and 21, divided by 4. Rest tremor score = the sum of item 20 divided by 5. Active tremor score = the sum of item 21 divided by 2. PIGD score = the sum of items 22–27 and 31, divided by 15 from. Rigidity score = the sum of item 22 divided by 5. Bradykinesia score = item 23.