Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 21;15:128. doi: 10.1186/s13020-020-00415-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 9 — Graphic abstract of IAV-induced acute lung injury. Influenza A virus infected host alveolar epithelial cells and caused necrosis and injury in lung. The innate immune response began with the virus recognition and was amplified through activation of HMGB-1 and TLR4 signaling pathway. Extensive production of cytokines, chemokines produced by inflammation cells and amounts of peroxide products released from neutrophils exacerbated the injury of lung and multi organ failure in liver, thymus and spleen (red arrow). INAE treatment alleviated the acute lung injury and multi organ damage (green arrow) through the effects of anti-virus, anti-inflammatory and anti-oxidation