Table 1.
Patient characteristics.
| L-TILs/ADJ (n = 106) |
L-TILs /No-ADJ (n = 437) |
H-TILs/ADJ (n = 31) |
H-TILs/No-ADJ (n = 104) |
Total (n = 678) |
P-value | |
|---|---|---|---|---|---|---|
| Age at diagnosis, years | <0.00011 | |||||
| Median (IQR) | 66 (60–71) | 77 (71–83) | 66 (63–71) | 75 (67–81) | 75 (67–81) | |
| Range | 31–86 | 30–98 | 30–79 | 32–100 | 30–100 | |
| Sex, n (%) | 0.602 | |||||
| Female | 56 (52.8) | 203 (46.5) | 13 (41.9) | 51 (49.0) | 323 (47.6) | |
| Male | 50 (47.2) | 234 (53.5) | 18 (58.1) | 53 (51.0) | 355 (52.4) | |
| Family History CRC, n (%) | 0.0042 | |||||
| No | 61 (66.3) | 326 (77.4) | 19 (65.5) | 85 (86.7) | 491 (76.7) | |
| Yes | 31 (33.7) | 95 (22.6) | 10 (34.5) | 13 (13.3) | 149 (23.3) | |
| Missing | 14 | 16 | 2 | 6 | 38 | |
| T4 Tumor, n (%) | 0.132 | |||||
| No | 99 (93.4) | 413 (94.5) | 26 (83.9) | 98 (94.2) | 636 (93.8) | |
| Yes | 7 (6.6) | 24 (5.5) | 5 (16.1) | 6 (5.8) | 42 (6.2) | |
| Grade, n (%) | 0.232 | |||||
| 2 | 54 (50.9) | 226 (51.7) | 14 (45.2) | 64 (61.5) | 358 (52.8) | |
| 3 | 52 (49.1) | 211 (48.3) | 17 (54.8) | 40 (38.5) | 320 (47.2) | |
| Poorly differentiated (high grade), n (%) | 0.232 | |||||
| No | 54 (50.9) | 226 (51.7) | 14 (45.2) | 64 (61.5) | 358 (52.8) | |
| Yes | 52 (49.1) | 211 (48.3) | 17 (54.8) | 40 (38.5) | 320 (47.2) | |
| Nodes Examined | 0.0141 | |||||
| Median (IQR) | 18 (12–24) | 16 (11–22) | 22 (13–30) | 16 (11–23) | 16 (11–23) | |
| Range | 4–63 | 1–60 | 7–47 | 3–55 | 1–63 | |
| Inadequate nodal harvest, n (%) | 0.092 | |||||
| No | 81 (76.4) | 321 (73.5) | 29 (93.5) | 77 (74.0) | 508 (74.9) | |
| Yes | 25 (23.6) | 116 (26.5) | 2 (6.5) | 27 (26.0) | 170 (25.1) | |
| Sidedness, n (%) | 0.932 | |||||
| Right/Transverse | 60 (56.6) | 244 (55.8) | 18 (58.1) | 55 (52.9) | 377 (55.6) | |
| Left | 46 (43.4) | 193 (44.2) | 13 (41.9) | 49 (47.1) | 301 (44.4) | |
| Tumor characteristics, n (%) | 0.432 | |||||
| Neither | 58 (54.7) | 256 (58.6) | 19 (61.3) | 54 (51.9) | 387 (57.1) | |
| Rupture | 2 (1.9) | 12 (2.7) | 2 (6.5) | 6 (5.8) | 22 (3.2) | |
| Obstruction | 46 (43.4) | 169 (38.7) | 10 (32.3) | 44 (42.3) | 269 (39.7) | |
| High risk of recurrence, n (%) | 0.262 | |||||
| No | 14 (13.2) | 49 (11.2) | 2 (6.5) | 18 (17.3) | 83 (12.2) | |
| Yes | 92 (86.8) | 388 (88.8) | 29 (93.5) | 86 (82.7) | 595 (87.8) | |
| Lymphovascular invasion, n (%) | 0.632 | |||||
| No | 104 (98.1) | 418 (95.7) | 30 (96.8) | 101 (97.1) | 653 (96.3) | |
| Yes | 2 (1.9) | 19 (4.3) | 1 (3.2) | 3 (2.9) | 25 (3.7) | |
| Perineural invasion, n (%) | 0.0072 | |||||
| No | 45 (42.5) | 195 (44.6) | 20 (64.5) | 62 (59.6) | 322 (47.5) | |
| Yes | 61 (57.5) | 242 (55.4) | 11 (35.5) | 42 (40.4) | 356 (52.5) | |
| Adjuvant chemotherapy, n (%) | <0.00012 | |||||
| No | 0 (0.0) | 437 (100.0) | 0 (0.0) | 104 (100.0) | 541 (79.8) | |
| Yes | 106 (100.0) | 0 (0.0) | 31 (100.0) | 0 (0.0) | 137 (20.2) |
Abbreviations: ADJ, adjuvant chemotherapy; CRC, colorectal cancer; H-TILs, high tumor infiltrating lymphocytes density; L-TILs, low tumor infiltrating lymphocytes density; no-ADJ, no adjuvant chemotherapy.
1Kruskal–Wallis p-value; 2Chi-Square p-value.