Table 3.

Multivariable analysis of OS and TTR using H-TILs/no-ADJ as reference.

	OS, HR (95% CI)	Pr > ChiSq #	P-value *	TTR, HR (95% CI)	Pr > ChiSq #	P-value *
H-TILs/ADJ ^	0.32 (0.15–0.68)	0.0030	<0.0001	0.25 (0.06, 1.07)	0.0618	0.0063
L-TILs/ADJ ^	0.30 (0.19–0.50)	<0.0001		0.44 (0.21, 0.93)	0.0310
L-TILs/no-ADJ ^	1.36 (1.02–1.82)	0.0373		0.99 (0.61, 1.61)	0.9665
Tumor Characteristics Rupture	1.73 (1.00–3.00)	0.0498	0.1095	3.44 (1.55, 7.61)	0.0023	0.0075
Tumor Characteristics Obstruction	1.15 (0.93–1.43)	0.1989		1.51 (1.01, 2.24)	0.0422
T4 Tumor	1.96 (1.28–2.99)	0.0018		2.53 (1.31, 4.90)	0.0056
Poorly differentiated (high grade)	1.31 (1.05–1.62)	0.0149		1.23 (0.84, 1.82)	0.2906
Perineural Invasion	1.28 (1.02–1.61)	0.0337		0.89 (0.59, 1.35)	0.5915
Lymphovascular Invasion	0.83 (0.47–1.46)	0.5211		1.79 (0.81, 3.95)	0.1494
Inadequate nodal harvest	1.57 (1.25–1.98)	0.0001		1.85 (1.23, 2.77)	0.0030

Abbreviations: ADJ, adjuvant chemotherapy; HR, hazard ratio; H-TILs, high tumor infiltrating lymphocytes density; l-TILs, low tumor infiltrating lymphocytes density; no-ADJ, no adjuvant chemotherapy; OS, overall survival; TTR, time to recurrence.

Models were adjusted for: T4, inadequate nodal harvest, perineural invasion, lymphovascular invasion, poorly differentiated tumor, obstruction, rupture, and adjuvant chemotherapy, when applicable.

^ Reference group is H-TILs/no-ADJ; # P-value for each level compares to the reference; * P-value for difference across levels.