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. 2020 Dec 7;11:593468. doi: 10.3389/fphys.2020.593468

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Copyright © 2020 VanderVeen, Sougiannis, Velazquez, Carson, Fan and Murphy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of 5FU on skeletal muscle macrophage gene expression. (A) Relative gene expression of total macrophage genes, CD68 and Emr1 (F4/80), M1-like macrophage gene, Itgax (CD11c), and M2-like macrophage gene, Mrc1 (CD206). (B) Relative gene expression of pro-inflammatory genes, Interleukin (IL) 6, IL-1β, Interferon (IFN) γ, Tumor necrosis factor (TNF) α, and monocyte chemoattractant protein (MCP) 1. (C) Relative gene expression of anti-inflammatory genes IL-10 and transforming growth factor (TGF) β. Significance was set at p < 0.05. *Significantly different from Control using a student’s t-test.