Table 1.
Overview about tissue effects and targets of PCSK9.
| Organ | Biological effect/target | Disease |
|---|---|---|
| Brain | Apoptosis | Neuronal differentiation |
| BACE-1 | Alzheimer disease | |
| Kidney | LDL-R, lipid storage | Renal fibrosis |
| Blood vessels | LDL-R, cholesterol uptake | Atherosclerosis |
| ABCA-1, reverse cholesterol transport | Atherosclerosis | |
| CD36, platelet activity | Thrombosis | |
| Heart | Muscle contractility | Heart failure |
| Gastrointestinal tract | LDL-R, ApoB, TICE | not known* |
| Pancreas | LDL-R | Diabetes |
| Fat tissue | VLDL-R, fat storage | not known* |
| Skin | Cell cycling, apoptosis | Psioriasis |
| Bone | TRAF2, osteogenesis | not known |
| Ovaria | LDL-R | Polycystic ovary syndrome |
*
not specifically worked out but likely contribute to hypercholesterolemia.