Table R1.

Review table, role of NSPs of SARS-CoV-2.

S. No.	Protein	Function	Reference
1	NSP1	It is involved in host-range restriction in countering innate host antiviral response and in suppressing induction of apoptosis during early stages of infection to promote viral growth.	[2,3]
2	NSP2	Involved in disruption of intracellular host signaling during SARS-CoV infections.	[35]
3	NSP3	It is proposed to facilitate translation of the mRNA transcripts and to suppress host protein synthesis.	[[11], [12], [13], [14], [15]]
4	NSP4	Essential role is replication and the assembly of the replicative structures.	[36]
5	NSP5	Protease activity	[37]
6	NSP6	Generates autophagosomes from the endoplasmic reticulum and is involved in autophagy	[14,15]
7	NSP7	Primer-Independent RNA polymerase Activity	[38]
8	NSP8	Primase activity	[39]
9	NSP9	In complex with NSP 8, involved in RNA replication and virulence of virus.	[[20], [21], [22]]
10	NSP10	It is a cofactor for both the 2′O-methyltransferase activity of NSP16, and the N7-guanine-methyltransferase/exoribonuclease activities of NSP14	[[40], [41], [42]]
11	NSP11	Essential for replication	[43]
12	NSP12	RNA polymerase/Replicase activity	[44]
13	NSP13	Helicase and RNA TPase activity	[26]
14	NSP14	Methyl transferase and Exoribonuclease activity	[27,28],
15	NSP15	Uridylate-specific Endoribonuclease activity	[[29], [30], [31]]