Table 4.
Selected drugs and their detailed targets proteins.
| Drug_ID | Target Protein ID with Ligand code | Active sties with bond length | PyRx Binding energy and bonded residues | General Function of Target Proteina | Specific action of Target Proteina | Type of Target Proteina |
| DB01977 | 1owe, 675 | D205 = 2.8,2.9 | −7.5 | Serine-type endopeptidase activity | Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. | Urokinase-type plasminogen activator |
| S206 = 2.8 | D205 = 2.3 | |||||
| Q208 = 2.9 | S206 = 2.6 | |||||
| G234 = 2.9 | ||||||
| DB07132 a | 2pe1, 517 | T222 = 3.0 | −9.1 | Protein serine/threonine kinase activity | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB | 3-phosphoinositide-dependent protein kinase 1 |
| D223 = 3.3 | T222 = 2.6 | |||||
| K111 = 3.0 | E90 = 2.2 | |||||
| E209 = 2.2 | ||||||
| DB07535 | 2va5, C8C | D32 = 2.6,3.0 | −9.1 | Peptidase activity | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the genera | Beta-secretase 1 |
| D228 = 3.2 | T222 = 2.5 | |||||
| E90 = 2.3 | ||||||
| E209 = 2.2,2.7 | ||||||
a
Details taken from drug bank.