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. 2020 Sep 21;52(10):512–516. doi: 10.1152/physiolgenomics.00094.2020

Fig. 2.

Fig. 2.

Strain affects the level of disease-associated calcification in kidneys from KLOTHO-deficient (Kl/Kl) mice. A, B: calcium levels normalized to protein levels in kidneys from mice of the indicated strains, sexes, and genotypes are shown. Diseased Klotho mutant homozygotes of both sexes and strains have increased levels of renal calcium compared with controls. Note different y-axes (Ctrl B6 n = 18 females and 9 males, Ctrl 129 n = 15 females and 13 males). B: KLOTHO-deficient B6 female (n = 11) and male mice (n = 8) have less kidney calcification than 129 mice (n = 11 females and 14 males). C: relative to control healthy mice, 129 mice with KLOTHO deficiency develop more renal calcification than B6 mice. Mean values ± 95% confidence interval are shown.