. 2020 Aug 24;319(4):E744–E752. doi: 10.1152/ajpendo.00228.2020

Table 2.

Change from baseline (%) in oxidative stress and inflammation markers before and after salsalate treatment

	Before	After
Saturated fat ingestion (n = 8)
ROS generation	89 ± 13	42 ± 13^a
p47^phox mRNA content	29 ± 5	11 ± 2^a
p105 mRNA content	30 ± 3	12 ± 3^a
p65 mRNA content	28 ± 3	11 ± 2^a
TNFα mRNA content	18 ± 4	5 ± 2^a
TNFα secretion	24 ± 12	3 ± 6^a
Plasma TNFα	19 ± 4	7 ± 1^a
Hyperglycemic infusion (n = 5)
ROS generation	56 ± 9	23 ± 11^b
p47^phox mRNA content	27 ± 5	10 ± 2^b
p105 mRNA content	28 ± 4	12 ± 6^b
p65 mRNA content	23 ± 5	8 ± 4^b
TNFα mRNA content	36 ± 6	13 ± 3^b
TNFα secretion	26 ± 8	4 ± 7^b
Plasma TNFα	34 ± 7	16 ± 4^b

Values are expressed as means ± SE. mRNA, messenger ribonucleic acid; ROS, reactive oxygen species; TNFα, tumor necrosis factor-α. Significantly decreased after salsalate treatment (paired Student’s t test),

P < 0.02;

P < 0.03.