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Alteration landscape of the paired tumor tissue biopsies collected before (yellow headings) and after histological transformation (green headings). The numbers in the boxes correspond to the variant allele frequency of the mutation or the gene copy number for amplifications. Samples were analyzed using the Advanta Solid Tumor NGS Library Prep Assay (Fluidigm) and sequenced on a NextSeq platform (Illumina).
LC, lung carcinoma.
