Table I.

Summary of all literature-documented cases of PDD due to HPyV6 or HPyV7

Case report	Age (Y)/Sex	Immune status	Clinical presentation	Treatments attempted	Outcome
Ho et al4	1.73/M 2.72/M	1.Single lung transplant recipient on alemtuzumab, prednisone, azathioprine, and tacrolimus 2.Double lung transplant recipient on alemtuzumab, tacrolimus, mycophenolic acid, and prednisone	1.Multiple pruritic, brownish-pink, thin, scaly papules and plaques on the trunk and neck sparing the acral areas and face 2.Pruritic, brown, well-defined thin papules and plaques on the trunk, axillae, neck, buttocks, and legs	1.Topical corticosteroids and antihistamines 2.Topical corticosteroids and diphenhydramine	1.Worsening progression of symptoms 2.Diphenhydramine led to minimal improvement, and topical corticosteroids worsened rash
Nguyen et al2	1.52/M 2.36 /F 3.54/M	1.Kidney and pancreas transplant recipient on tacrolimus and rapamycin 2.HIV/AIDS 3.None at time of diagnosis but was hospitalized for sepsis, parapharyngeal abscess, and pneumonia	1.Pruritic rash present for over 2 years 2.Severe pruritic rash worsening over 12 months 3.Pruritic rash worsening over 2 years followed by resolution over several years	1.Unknown 2.Unknown 3.Unknown	1.Patient deceased 2.Initial worsening for 2 years and then several years of resolution with no immunosuppression 3.Patient deceased
Smith et al5	59/M	Bilateral lobar (living) transplant recipient on prednisone and tacrolimus	Diffuse, gray, lichenified plaques with confetti-like islands of sparing on the trunk and proximal extremities and generalized pruritus	•Oral steroid •Topical steroid •Antihistamine •Topical (1% and 3%) cidofovir	•Oral steroid: minimal improvement of rash and pruritus •Topical steroid: no relief •Antihistamine: no relief •Topical (1% and 3%) cidofovir: clinical improvement of the rash on the flanks, near clearance on the extremities, and resolution of generalized pruritus
Canavan et al3	48/M	Cardiac transplant recipient on sirolimus and tacrolimus	Severely pruritic, pink to gray macules, thin papules, and plaques on the trunk and extremities, sparing acral areas and the face	Cyproheptadine, doxepin, emollients, topical corticosteroids, parmoxine cream, intravenous cidofovir, and oral acitretin 25 mg	No improvement with topical treatments or antihistamines. Temporary improvement with intravenous cidofovir with subsequent relapse within 4-6 weeks. Complete clinical resolution with oral acitretin
Current report	44/M	Kidney and pancreas transplant recipient on tacrolimus and everolimus	Hyperpigmented scaly patches all over body and prominent follicular spines on the elbows and palms	Oral acitretin 25 mg daily	Complete clearing of patches with improvement in keratotic papules at 1-month follow-up

HPyV6, Human polyomavirus 6; HPyV7, human polyomavirus 7; PDD, pruritic and dyskeratotic dermatosis.