TABLE 3.
Pharmacokinetic parameters under postprandial conditions.
| Parameters | Mean ± SD (CV%) | |
|---|---|---|
| Test (N = 71) | Reference (N = 72) | |
| Tmax (h) | 0.75 (0.17, 3.00) | 1.00 (0.17, 3.00) |
| Cmax (ng/ml) | 4.33 ± 2.43 (56.18) | 4.36 ± 2.98 (68.36) |
| AUC0–t (h ng/ml) | 4.93 ± 1.36 (27.60) | 4.81 ± 1.38 (28.75) |
| AUC0–∞ (h ng/ml) | 5.01 ± 1.39 (27.65) | 4.89 ± 1.40 (28.67) |
| t½ (h) | 1.82 ± 0.99 (54.37) | 1.97 ± 3.02 (153.34) |
AUC0–t indicates area under the concentration-time curve from 0 to t; AUC0–∞, area under the concentration-time curve from 0 to infinity; Cmax, maximum concentration; CV, coefficient of variation; t½, half-life of elimination; Tmax, time to Cmax. Tmax was represented as median (min, max) (CV%).