Fig. 9.

(A) Typical in vivo optical images of male H22-bearing Kunming mice post-intravenous injection of saline (control group a), free ASODN (b), DGL-ASODN (c), DGL-FA-ASODN (d), DGL-FA-ASODN-DCA (e), and GEL-DGL-FA-ASODN-DCA (f) with a dosage of 0.195 mg ASODN—Cy5.5 per kg BW by tail vein, respectively. (B) Quantitative assay of the fluorescence intensity from the tumors of different groups based on in vivo optical images. (C) Optical images from the representative tissues from different groups. (D) Quantitative assay of the fluorescence intensity from dissected tumors. Images were taken using the IVIS Imaging System (IVIS Lumina II, USA) in anesthetized mice with 5% chloral hydrate at 24 h post administration. The system uses color coding of fluorescence with red coding for high levels of fluorescence and blue color for low levels. Excitation = 675 nm, emission = 695 nm. The data are expressed as mean ± SD (n = 3).