Table 1.
Composition of prepared proniosomes.*
| Batch Code | Tramadol HCl | Span 20 | Span 40 | Span 60 | Span 80 | Tween 20 | Tween 40 | Tween 60 | Tween 80 | Lecithin | Cholesterol |
|---|---|---|---|---|---|---|---|---|---|---|---|
| F1 | 100 | 1800 | – | – | – | – | – | – | – | 1800 | 200 |
| F2 | 100 | – | 1800 | – | – | – | – | – | – | 1800 | 200 |
| F3 | 100 | – | – | 1800 | – | – | – | – | – | 1800 | 200 |
| F4 | 100 | – | – | – | 1800 | – | – | – | – | 1800 | 200 |
| F5 | 100 | – | – | – | – | 1800 | – | – | – | 1800 | 200 |
| F6 | 100 | – | – | – | – | – | 1800 | – | – | 1800 | 200 |
| F7 | 100 | – | – | – | – | – | – | 1800 | – | 1800 | 200 |
| F8 | 100 | – | – | – | – | – | – | – | 1800 | 1800 | 200 |
| F9 | 60 | – | – | – | 1800 | – | – | – | – | 1800 | 200 |
| F10 | 140 | – | – | – | 1800 | – | – | – | – | 1800 | 200 |
⁎
All compositions are expressed in mg.