Table 1.
Demographic, clinical and general neuropsychological assessment performance for all groups
| LPA | Control | Group effect | |
|---|---|---|---|
| N | 43 | 30 | |
| Sex (M:F) | 19:24 | 14:16 | 2 < 0.001; P > 0.1 |
| Age (years) | 70.5 (7.9) | 72.6 (2.8) | t = 1.57; P = 0.12 |
| Education (years) | 12.2 (3.2) | 13.2 (2.0) | t = 1.6; P = 0.11 |
| Disease duration (years) | 2.7 (2.0) | ||
| Disease severity (CDR-FTLD SoB) | 5.2 (3.5) | ||
| CBI-R total (%) | 33.8 (22.8) | 4.3 (4.8) | W = 59.5; P < 0.0001 |
| CBI-R memory (%) | 11.8 (6.2) | 1.9 (2.6) | W = 77.5; P < 0.0001 |
| ACE-R total (100)a | 61.0 (15.4) | 95.0 (3.3) | W = 1286; P < 0.0001 |
| Neuropsychological tests | |||
| ACE-R attention total (18) | 12.4 (3.3) | 17.7 (.5) | W = 1258; P < 0.0001 |
| ACE-R memory total (26) | 13.8 (5.8) | 24.1 (1.7) | W = 1229.5; P < 0.0001 |
| ACE-R fluency total (14) | 4.5 (2.8) | 12.2 (1.5) | W = 1281.5; P < 0.0001 |
| ACE-R language total (26) | 17.6 (5.3) | 25.2 (.9) | W = 1202.5; P < 0.0001 |
| ACE-R visuospatial total (16) | 6.5 (6.1) | 15.6 (.8) | W = 1224; P < 0.0001 |
| SYDBAT naming (30) | 15.4 (6.9) | 26.6 (2.4) | W = 1095.5; P < 0.0001 |
| SYDBAT comprehension (30) | 26.1 (2.5) | 29.0 (1.5) | W = 924; P < 0.0001 |
| SYDBAT repetition (30) | 25.6 (5.5) | 29.8 (.5) | W = 923.5; P < 0.0001 |
| SYDBAT semantic (30) | 25.3 (3.2) | 28.0 (1.5) | W = 844; P < 0.0001 |
| Digit span forward (16) | 6.5 (2.5) | 11.2 (2.1) | W = 1083; P < 0.0001 |
| Digit span backward (16) | 3.6 (2.0) | 8.2 (2.4) | t = 8.3; P < 0.0001 |
| ROCF copy (36) | 24.6 (8.9) | 32.8 (3.1) | W = 859; P < 0.0001 |
| ROCF delayed recall (36) | 8.8 (4.9) | 17.5 (4.9) | W = 870; P < 0.0001 |
| TMT B-A time difference (s) | 165.1 (152.6) | 42.6 (20.6) | W = 45; P < 0.0001 |
Notes. Maximum test scores reported in brackets; For all groups, mean and standard deviation reported; 2 = Chi-square value; based on the Shapiro–Wilk test outputs, t-test (t-value) employed when data met normality assumptions or Wilcoxon–Mann–Whitney test (W-value) employed when data violated normality assumptions; For all statistical comparisons, P-values bolded if P < 0.05.
23/43 (53%) LPA patients had ACE-III scores which were converted into ACE-R scores (see Methods section).
ACE-R = Addenbrooke’s Cognitive Examination – Revised; CBI-R = Cambridge Behavioural Inventory – Revised; CDR-FTLD SoB = Clinical Dementia Rating – Frontotemporal Lobar Degeneration Sum of Boxes; LPA = logopenic progressive aphasia; ROCF = Rey-Osterrieth Complex Figure; SYDBAT = Sydney Language Battery; TMT B-A = Trail Making Test parts B – A.