Table 3.

VBM results showing regions of grey and white matter intensity that correlate with PCA-generated Factor 1 and Factor 2 scores in the LPA group

Regions	Side	Number of voxels	Peak MNI co-ordinates			t-value
			x	y	z
Speech production and verbal memory factor (Factor 1)
Middle frontal gyrus	Left	146	−43	33	42	4.09
Visuospatial and executive factor (Factor 2)
Supramarginal gyrus and angular gyrus, extending into the superior parietal and insular cortices through the superior longitudinal fasciculus, and into superior/middle temporal gyrus through the inferior longitudinal fasciculus	Right	3694	51	−29	42	5.14
Supramarginal and angular gyrus	Right	820	48	−50	48	4.32
Superior/middle temporal gyrus and underlying middle/inferior longitudinal fasciculus components	Right	760	56	−55	8	4.4
Middle/inferior temporal gyrus and underlying inferior longitudinal fasciculus component	Right	510	58	−48	−21	3.85
Middle temporal gyrus and underlying inferior longitudinal fasciculus component	Right	388	64	−34	−3	4.42
Precentral gyrus connecting to middle/inferior frontal gyrus through superior longitudinal fasciculus	Right	337	40	−8	53	3.9
Middle/inferior temporal gyrus extending into temporal pole through underlying inferior longitudinal fasciculus component	Right	202	42	3	−28	3.6
Postcentral gyrus and supramarginal gyrus	Right	188	61	−16	22	3.83
Fusiform gyrus extending towards lingual gyrus, parahippocampal cortex and cerebellum	Right	175	25	−59	−11	3.69

Note. MRI data were available for 35 LPA patients. Clusters presented above emerged as significant in the VBM analyses at a threshold of P < 0.001 uncorrected with a cluster threshold of 100 contiguous voxels. Age and total intracranial volume were included as covariates in the analyses.

LPA = logopenic progressive aphasia; MNI = Montreal Neurological Institute.