Table 3.

Sensitivity Analysis of Patient and Caregiver Cost of Illness Due to Enteric Fever: Direct Medical, Direct Nonmedical, Indirect, and Total Costs When Excluding Outliers, Karachi, Pakistan, September 2016–December 2018

	Patients Who Only Reported Outpatient Care Expenses and did not Have a Nontraumatic Terminal Ileal Perforationa				Patients Who Reported Inpatient Care Expenses or Had a Nontraumatic Terminal Ileal Perforationb				All Patients
Cost Type	n	Median	25th Pctl	75th Pctl	n	Median	25th Pctl	75th Pctl	n	Median	25th Pctl	75th Pctl
Direct medical costs, 2018 US$
Total direct medical costs	809	123.17	45.28	346.40	139	228.03	109.49	411.61	948	133.57	49.50	360.72
Registration	393	4.12	2.14	16.46	48	4.12	1.68	12.55	441	4.12	2.06	16.46
Clinical examination	25	4.12	1.65	6.84	19	5.76	4.12	15.40	44	4.70	2.76	10.29
Inpatient stay	0	N/A	N/A	N/A	25	74.09	23.09	90.55	25	74.09	23.09	90.55
Laboratory tests	202	25.66	10.70	49.39	50	32.11	8.23	82.32	252	25.66	10.07	51.32
Drugs and medications	359	12.35	6.59	34.21	88	29.29	10.07	82.32	447	14.82	6.84	42.77
Other servicesc	7	6.59	2.57	11.12	34	24.70	8.55	41.16	41	18.82	8.23	41.16
Direct nonmedical costs, 2018 US$
Total direct nonmedical costs	683	4.28	2.47	9.88	120	23.87	8.23	75.96	803	5.13	2.57	13.17
Transport	682	4.28	2.47	8.55	126	16.46	8.23	45.28	808	4.94	2.57	11.28
Food, lodging, childcare	76	32.93	16.46	82.32	63	49.39	25.66	82.32	139	41.16	18.52	82.32
Indirect costs: patient
Days spent seeking care	864	1.29	0.13	4.00	126	8.00	6.00	12.00	990	2.46	0.15	5.00
Days unable to work	27	14.00	4.00	48.00	40	53.50	30.00	80.00	67	30.00	14.00	60.00
Days of sick leave	51	14.00	7.00	28.00	3	20.00	10.00	60.01	54	14.50	7.00	28.00
School days lost	392	30.00	15.00	45.00	35	58.00	22.00	90.00	427	30.00	15.00	50.00
Total productivity loss, 2018 US$	74	96.30	46.38	198.61	40	311.16	161.56	479.98	114	141.61	68.79	275.14
Indirect costs: caregiver
Days spent accompanying the patient seeking care	846	3.26	0.33	9.00	125	16.00	10.13	24.00	971	4.31	0.42	11.00
Days unable to work	164	5.00	2.00	12.00	96	15.00	8.00	22.00	260	8.00	3.00	15.00
Days of sick leave	211	3.00	1.17	5.00	10	4.50	2.00	7.00	221	3.00	1.33	5.00
Total productivity loss, 2018 US$	368	20.69	13.24	46.34	102	82.75	41.34	127.53	470	27.51	13.24	68.79
Cost of illness
Total cost of illness per case, 2018 US$	838	141.68	57.63	397.91	137	460.90	244.91	833.13	975	178.76	68.87	455.89

Abbreviations: N/A, not applicable because it excludes inpatient care; Pctl, percentile.

^a Expenses by patients who only reported outpatient care, regardless of patient recruitment location (outpatient care, inpatient care, hospital laboratory, surgery) and excluding patients with nontraumatic terminal ileal perforation.

^b Expenses by patients with nontraumatic terminal ileal perforation, regardless of whether they reported inpatient care, and patients reporting inpatient care expenses, regardless of patient recruitment location (outpatient care, inpatient care, hospital laboratory, surgery).

^c Other services that patients did not report in the above categories (eg, medical materials or equipment for surgery).