Figure 2.
Subventricular glial nodules are commonly present in the human subventricular zone and express proliferation and stem cell markers. (A, B) SGN in the lateral ventricle of a 2-year-old male donor (NBB 1997-017, scale bar 100 μm) and a 93-year-old female donor (NBB 2005-063, scale bar 50 μm), being denuded of ependyma, hypercellular and showing accumulation of thionin-positive fibrous tissue. (C) No significant correlation was found between age and SGN occurrence (Cox–Snell’s R2 = 0.1004, χ2(1) = 2.750, P = 0.0972). (D–F) SGNs express NSC (nestin, GFAPδ and SOX2), astrocyte (vimentin) and proliferation (PCNA) markers. (G) GFAPα is not specifically expressed by SGNs (NBB 2005-073, male, 87 years). Scale bars C–F = 10 μm.